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Source: NIH
Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
Shuangshi Wei 1, Shengbao Duan 2, Xiaomei Liu 1, Hongmei Wang 1, Shaohua Ding 1, Yezhou Chen 1, Jinsong Xie 1, Jingjing Tian 1, Nong Yu 3, Pingju Ge 4, Xinglin Zhang 4, Xiaohong Chen 4, Yong Li 5, Qinglin Meng 6
Affiliations expand
PMID: 33191178 PMCID: PMC7608017 DOI: 10.1016/j.intimp.2020.107172
Free PMC article
Abstract
The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.
Source: NIH
Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
Shuangshi Wei 1, Shengbao Duan 2, Xiaomei Liu 1, Hongmei Wang 1, Shaohua Ding 1, Yezhou Chen 1, Jinsong Xie 1, Jingjing Tian 1, Nong Yu 3, Pingju Ge 4, Xinglin Zhang 4, Xiaohong Chen 4, Yong Li 5, Qinglin Meng 6
Affiliations expand
PMID: 33191178 PMCID: PMC7608017 DOI: 10.1016/j.intimp.2020.107172
Free PMC article
Abstract
The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.
Keywords: Chicken Egg Yolk Antibodies; IgY; Neutralizing agent; SARS-CoV-2; Spike protein variants.
Copyright © 2020 Elsevier B.V. All rights reserved.
To continue reading and to view diagrams please go to the NIH webpage.
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News update for 6 February 2023:
Torching the chickens:
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