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Source: UK Column
by DR MIKE WILLIAMS | Sunday, 12th September 2021
In life and in science, changes have consequences. With hindsight, the bad ones are easy to see, some may argue. But when we examine the natural consequences of changes in the arena of Covid vaccine science, one might be forgiven for asking: surely someone must have cautioned against doing that? Of course it behoves us to state here, before we examine those consequences: that's why new drug/vaccine products are supposed to be thoroughly tested before they are given to large populations.
Source: UK Column
In life and in science, changes have consequences. With hindsight, the bad ones are easy to see, some may argue. But when we examine the natural consequences of changes in the arena of Covid vaccine science, one might be forgiven for asking: surely someone must have cautioned against doing that? Of course it behoves us to state here, before we examine those consequences: that's why new drug/vaccine products are supposed to be thoroughly tested before they are given to large populations.
In 2005, Drs. Weissman and Kariko discovered a way to protect foreign mRNA from the body's immune system. That scientific milestone would be key to the advancement of the mRNA vaccines in 2020.
Recently, the University of Pennsylvania Tweeted a picture of the Drs. Weissman and Kariko receiving their Covid vaccination, and reminding us of that milestone. One tweet commenting that they should receive the Nobel prize for their discovery.
The fundamental change discovered by Weissman and Kariko was that nucleoside modification could protect mRNA from the body's immune defences:
This discovery was adopted in the mRNA technology used in Covid vaccines, in order that the foreign vaccine mRNA could enter cells without being destroyed. Below is the mRNA code from the Pfizer vaccine demonstrating the modified Uridine nucleoside by denoting it as Ψ (modified) instead of its natural form U (Uridine). To be precise: every Uridine (U) has been replaced by 1-methyl-3'-pseudouridylyl (Ψ).
By modifying the Uridine in the Pfizer vaccine mRNA code, the foreign mRNA is able to bypass part of the body's first line of defence — the Innate Immune System.
The body possesses two broad parts to its immune system: innate and specific. The innate is the first to go into action against foreign invaders, including foreign mRNA from a vaccine.
How does that simple removal of one letter of code from mRNA achieve that?
Recently, the University of Pennsylvania Tweeted a picture of the Drs. Weissman and Kariko receiving their Covid vaccination, and reminding us of that milestone. One tweet commenting that they should receive the Nobel prize for their discovery.
Drs. Drew Weissman & Katalin Karikó—whose mRNA discovery at @PennMedicine helped pave the way for #COVID19 vaccines—received their first dose of the @pfizer/@BioNTech_Group shot together. They say, “The benefit is huge & there’s little to no risk.” https://t.co/Lg36CgMZMR pic.twitter.com/m64aoYTr3v
— Penn Medicine (@PennMedicine) December 23, 2020
@kkariko An exceptional image deserving Pulitzer Prize for Photography! A passionate, hard-working Scientist who believed in her discovery and succeded to turn it into something extraordinary for the humanity! And now for herself! A great Lady of Science deserving Nobel Prize!
— Florin-Dan (@florindanpopesq) December 23, 2020
The fundamental change discovered by Weissman and Kariko was that nucleoside modification could protect mRNA from the body's immune defences:
Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNATheir key discovery, that by modifying the RNA code (modifying the nucleoside uridine), resulted in ablating the innate immune response, involved toll-like receptors (TLR).
Katalin Karikó 1, Michael Buckstein, Houping Ni, Drew Weissman
PMID: 16111635 DOI: 10.1016/j.immuni.2005.06.008
We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity.
This discovery was adopted in the mRNA technology used in Covid vaccines, in order that the foreign vaccine mRNA could enter cells without being destroyed. Below is the mRNA code from the Pfizer vaccine demonstrating the modified Uridine nucleoside by denoting it as Ψ (modified) instead of its natural form U (Uridine). To be precise: every Uridine (U) has been replaced by 1-methyl-3'-pseudouridylyl (Ψ).
The body possesses two broad parts to its immune system: innate and specific. The innate is the first to go into action against foreign invaders, including foreign mRNA from a vaccine.
How does that simple removal of one letter of code from mRNA achieve that?
It does so by affecting Toll Like Receptors (TLR): the alarm signal of the Innate Immune System.
The key TLRs affected are TLR 3, TLR 7 and TLR 8. They act as sentries, whose job is to recognise foreign invaders by way of their form or patterns; a bit like an aircraft spotter in World War II. If the wrong type of shape is recognised in the sky then alarm bells sound and anti-aircraft fire kicks in. In the case of TLRs, the immune system gets activated.
What if you could by-pass those spotters? No alarms, no immune system response; and your payload, foreign mRNA in this example, gets through safely. Then your drug/vaccine has a much greater chance of working.
At that point in the original experiments to discover how to turn off toll-like receptors (and subsequently in the design of the vaccines), the question should have been asked: but what would be the consequences of switching off that important early warning system?
If that question was raised it appears to have fallen on deaf ears and not been answered until, possibly, now.
Please go to the UK Column to read more.
The key TLRs affected are TLR 3, TLR 7 and TLR 8. They act as sentries, whose job is to recognise foreign invaders by way of their form or patterns; a bit like an aircraft spotter in World War II. If the wrong type of shape is recognised in the sky then alarm bells sound and anti-aircraft fire kicks in. In the case of TLRs, the immune system gets activated.
What if you could by-pass those spotters? No alarms, no immune system response; and your payload, foreign mRNA in this example, gets through safely. Then your drug/vaccine has a much greater chance of working.
At that point in the original experiments to discover how to turn off toll-like receptors (and subsequently in the design of the vaccines), the question should have been asked: but what would be the consequences of switching off that important early warning system?
If that question was raised it appears to have fallen on deaf ears and not been answered until, possibly, now.
Please go to the UK Column to read more.
________
Look out...break down the body's natural immune system (sabotage) and you could possibly be opening yourself up to this:
'Healthy' Mom Dies Of Cancer, Allegedly Thought She Just Had COVID-19 Vaccine Side Effects
Look out...break down the body's natural immune system (sabotage) and you could possibly be opening yourself up to this:
'Healthy' Mom Dies Of Cancer, Allegedly Thought She Just Had COVID-19 Vaccine Side Effects
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